Tinnitus in a patient with beta-thalassaemia intermedia on long-term treatment with desferrioxamine.
نویسندگان
چکیده
A women with beta-thalassemia intermedia, and iron overload following many years' treatment with oral iron, was treated with subcutaneous desferrioxamine. During the course of this treatment she developed tinnitus, which was considered to be a rare complication of the use of this chelating agent. The mechanism of this effect is not understood.
منابع مشابه
Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia.
BACKGROUND Despite the introduction of the parenteral iron chelator desferrioxamine more than 30 years ago, 50% of patients with thalassaemia major die before the age of 35 years, predominantly from iron-induced heart failure. The only alternative treatment is oral deferiprone, but its long-term efficacy on myocardial iron concentrations is unknown. METHODS We compared myocardial iron content...
متن کاملThalassaemia Intermedia : A Genetic Study in 11 Patients TABLE
Beta-thalassaemia is a hereditary defect in the synthesis of beta-polypeptide chains of haemoglobin. Most patients with beta-thalassaemia can be classified, both genetically and haematologically, into those with the homozygous form of the disease, and those with the heterozygous disease or thalassaemia minor. However, in clinical practice one occasionally encounters a patient with thalassaemia ...
متن کاملThalassaemia intermedia: a genetic study in 11 patients.
Beta-thalassaemia is a hereditary defect in the synthesis of beta-polypeptide chains of haemoglobin. Most patients with beta-thalassaemia can be classified, both genetically and haematologically, into those with the homozygous form of the disease, and those with the heterozygous disease or thalassaemia minor. However, in clinical practice one occasionally encounters a patient with thalassaemia ...
متن کاملبررسی فراوانی فاکتور V لیدن (G1691A)، پروترومبین G20210A و تغییر C667T در ژن سازنده آنزیم متیلن تتراهیدروفولات ردوکتاز (MTHFR) در بیماران تالاسمی ماژور و اینترمدیا مراجعه کننده به مرکز تحقیقات تالاسمی در مقایسه با افراد سالم در شمال ایران
Background and purpose: Mutation in factor V Leiden (R506Q), mutation of G20210Â in prothrombin and mutation of Ç667T in methylenetetrahydrofolate reductase (MTFHR) are part of genetic variant that increase the risk of thrombosis. The purpose of this study was to define the frequencies of three risk factors among thalassaemia major and thalassaemia intermedia compared with the normal subjects...
متن کاملLogarithmic quantitation model using serum ferritin to estimate iron overload in secondary haemochromatosis.
Nineteen children and adolescents receiving repeated transfusions and subcutaneous desferrioxamine treatment were investigated in an attempt to quantitate iron overload non-invasively. Before patients were started on desferrioxamine individual relationships were correlated for 12 to 36 months between transfused iron, absorbed iron estimated gastrointestinally, and increasing serum ferritin conc...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 57 671 شماره
صفحات -
تاریخ انتشار 1981